Norman Ende, Ruifeng Chen and Alluru S. Reddi, Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA

Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood glucose levels, survival, and insulitis in nonobese diabetic (NOD) mice with autoimmune type 1 diabetes...