Lifeline Cord Blood

Laboratory Investigation

Summary: Recent findings suggest that bone marrow (BM) cells have the capacity to differentiate into a variety of cell types including endocrine cells of the... Context: Stem cells are self-renewing elements that can generate many cell types in the body and are found in both adult and fetal tissue. Cell therapy using stem cells and their...

Linda von Wartburg

Today, about four percent of Americans bank their children's cord blood just in case it might come in handy, and more are doing it every day. Now a small study announced at the 67th Scientific Sessions of the American Diabetes Association has found that infusions of umbilical cord blood may preserve insulin production...

Tom Curtis, University of Texas Medical Branch at Galveston

In a fundamental discovery that someday may help cure type1 diabetes by allowing people to grow their own insulin-producing cells for a damaged or defective pancreas, medical researchers here have reported that they have engineered adult stem cells derived from human umbilical cord blood to produce insulin...

Natural forms of arthritis treatment are popular. Stem cells are about as natural as one can get. What are mesenchymal stem cells part one. A discussion of these important stem cells to restoring cartilage and other connective tissue...

12/07/2012

by Aaron Saenz

It is a villain that goes by many names: Type I, Juvenile onset, Diabetes Mellitus. More than 15,000 young people in the United States develop Type I diabetes each year, making them about twice as likely to die as their peers at every stage in their life. But there is a new superhero in the fight against Type I diabetes: Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation...

Four-month-old Ruby Gonzalez is part of a study at University Hospital looking for ways to reduce the risk of diabetes early in life. What if the risk for health problems like obesity and diabetes could be controlled in babies? Or better yet…before they’re even born? That’s the premise behind a new study in San Antonio using the youngest of volunteers.

Nature Biotechnology 21, 755 - 756 (2003) doi:10.1038/nbt0703-755

Bone marrow stem cells promote the regeneration of pancreatic a-cells in a mouse model of diabetes mellitus. The incidence of diabetes mellitus, a disease of insulin deficiency and elevated blood sugar levels, is increasing rapidly throughout the world. The number of diabetics worldwide was 151 million in 2000 and is projected to reach 221 million by 2010...

Journal of the American Medical Association

Context: In 2007, the effects of the autologous non-myeloablative hematopoietic stem cell transplantation (HSCT) in 15 patients with type 1 diabetes mellitus (DM) were reported. Most patients became insulin free with normal levels of glycated haemoglobin A1c (HbA1c) during a mean 18.8-month follow-up...

By Maggie Fox, Health and Science Editor, Reuters

Stem cells taken from the umbilical cords of newborns can be engineered to produce insulin and may someday be used to treat diabetes, U.S. and British researchers reported on Friday. They said they were able to first grow large numbers of the stem cells and then direct them to resemble the insulin-producing cells of the pancreas that are damaged in diabetes...

25/05/2007

In the therapy, the patient’s immune cells cultures with cord blood stem cells and returns only the ‘educated’ immune cells to the patient’s circulation.
The therapy is believed to provide benefits because abnormalities in multiple types of immune cells contribute to the autoimmunity in type1 diabetes and the insulin resistance in type 2 diabetes.

Norman Ende, Ruifeng Chen and Alluru S. Reddi, Department of Pathology and Laboratory Medicine, UMDNJ-New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA

Several studies have shown that transplantation of embryonic stem cells into diabetic animals either improved or normalized blood glucose levels. In this study, we examined the dose-dependent effect of early (prediabetic stage) intravenous administration of human umbilical cord blood (HUCB) mononuclear cells on blood glucose levels, survival, and insulitis in nonobese diabetic (NOD) mice with autoimmune type 1 diabetes...

Medical News Today

In a small pilot study, transfusion of stored, autologous (i.e. the person's own), umbilical cord blood into a group of children newly diagnosed with type 1 diabetes appears to have reduced their disease severity, possibly re-setting the immune system and slowing the destruction of their insulin-producing cells, according to a report presented today at the American Diabetes Association's 67th Annual Scientific Sessions...

Four-year-old girl makes history in world-first attempt to prevent type 1 diabetes

Isla Robinson is a very special little girl. At four years old she might not be old enough to understand it, but on Wednesday she made scientific history.

Andy Coghlan, Exclusive from New Scientist

Tantalising experiments that seem to have made human blood cells start producing insulin have raised the prospect of a new treatment for diabetes. Although the treatment has only been tried in mice so far, it might mean people can be cured with implants of their own cells...

Mesenchymal stem cells for osteoarthritis therapy

Important news for diabetics today: A new way to treat them; with cord blood, Dr. Bruce Hensel reported. "Cord blood is rich in stem cells: This research is looking at how giving cord blood will affect young newly diagnosed diabetics," Dr. Hensel said...

The immune system is poised to attack and destroy insulin-producing islet cells. DRI's Dr. Norma Kenyon reports on how mesenchymal stem cells may be used to promote the survival and long-term function of insulin-producing cells. The DRI leads the world in cure-focused research, pioneering new cell-based therapies to restore natural insulin production in those with diabetes...

Main Category: Diabetes News (UK)

A study carried out in Argentina by a team of researchers from a Not-For-Profit Organization called 'Don Roberto Fernandez Vina Foundation' (San Nicolas- Buenos Aires, Argentina) demonstrated that stem cells implanted into type 2 diabetes patients...

A cell used to treat immune-related diseases has been found to spare islet cells from destruction, reversing type 1 diabetes.

Mesenchymal stem cells (MSCs) were studied by researchers at the Harvard-affiliated Brigham and Women’s Hospital (BWH), with their results published in the journal Stem Cells.