Could stem cells be used to create new lungs?

Scientists have succeeded in transforming human stem cells into functional lung and airway cells, thus giving way to the possibility of generating lung tissue for transplant using a patient’s own cells. The study by Columbia University Medical Center (CUMC) researchers has significant potential for modelling lung disease, screening drugs, studying human lung development, and, ultimately, generating lung tissue for transplantation.

Read more

Diabetes alert: Stem Cell Educator therapy is safe and effective for treatment

In the therapy, the patient’s immune cells cultures with cord blood stem cells and returns only the ‘educated’ immune cells to the patient’s circulation.
The therapy is believed to provide benefits because abnormalities in multiple types of immune cells contribute to the autoimmunity in type1 diabetes and the insulin resistance in type 2 diabetes.

Read more

Lung Regeneration

Regenerative medicine has the potential to provide innovative new therapies for people with lung diseases, including chronic obstructive pulmonary disease (COPD), pulmonary fibrosis, cystic fibrosis, pulmonary arterial hypertension and bronchiolitis obliterans....

Read more

Need to Know: Regenerative medicine

How cord blood, stem cells and progenitor cells are the next frontier of innovative therapies.

 

In this week’s “TechKnow,” we meet baby Grace, who is part of an innovative FDA study that uses her umbilical cord blood—banked after her birth—to help treat hydrocephalus, a condition that causes swelling of the brain. It’s part of a movement towards “regenerative medicine” that sounds like sci-fi but is grounded in decades of research.

Read more

New Stem Cell Method Sheds Light on a Tell-tale Sign of Heart Disease

The team, led by Morgridge Institute Fellow Dave Vereide, describes in the Jan. 9, 2018 issue of Stem Cell Reports a new method of creating human arterial endothelial cells from cord blood and adult bone marrow sources. These cells, which have been notoriously difficult to grow in stable quantities, are essential to any future tissue engineering efforts to combat heart disease.

Read more

New Treatment For Children With Cerebral Palsy Uses Stem Cells From Their Own

There’s some exciting news for families who have children with cerebral palsy. A potential treatment using stem cells could be the first effective way to repair the parts of the brain damaged from the condition.
The cells come from a child’s own umbilical cord blood that was banked at birth. It later became clear that some children had suffered a brain injury around birth, resulting in cerebral palsy.

Read more

Protein in Human Umbilical Cord Blood Rejuvenates Old Mice's Impaired Learning, Memory

When the older mice received human umbilical-cord blood plasma every fourth day for two weeks, many measures of hippocampal function improved notably. Plasma from older people, on the other hand, didn't help at all, while young-adult plasma induced an intermediate effect. And older mice's performance on the Barnes maze and other tests was stellar in comparison with mice of the same age who got injections of saline instead of plasma.
Something in umbilical cord blood was making old brains act younger.

Read more

Riding with confidence: a boy’s story of using his own cord blood

After a Phase I clinical trial demonstrated it is safe to use a child’s own cord blood for cerebral palsy, researchers designed a Phase II clinical trial to determine how effective cord blood may be in treating children with cerebral palsy. The Phase II trial results were recently published and the findings are encouraging.
The results show that when kids received an adequate dose of their own cord blood, both brain connectivity and motor function improved — essentially lessening the symptoms of the cerebral palsy.

Read more