Lifeline Cord Blood

Beike Biotechnology and Medistem, Inc. Report on 114 Patients Treated With Novel Cord Blood Stem Cell Protocol; New Approach Opens Door to Expanded Uses of Cord Blood Stem Cells

A three-year-old leukemia victim was given a life-saving infusion of her own cord blood, marking the first time a child with this disease served as their own blood donor, American doctors said. The little girl is now a thriving six-year-old six -- a tribute, say her doctors, to the pioneering transplant that helped her recover from radical chemotherapy...

Although umbilical cord blood is an accepted alternative to bone marrow for transplantation, allele-matched bone marrow is generally regarded as the preferred graft source. Our aim was to assess leukaemia-free survival after transplantations of these alternatives compared with present HLA-matching practices, and to assess the relative effect of cell dose and HLA match, and their potential interaction on leukaemia-free survival after cord-blood transplantation...

THERE have been at least two cases here where parents attempted to save their dying child by having another baby.

AT THE Singapore General Hospital (SGH), which has been pioneering efforts in cord blood research here, 16 cord blood transplants have been performed on adults, said Dr William...

University of Minnesota researchers report that umbilical cord blood transplants may offer blood cancer patients better outcomes than bone marrow transplants, according to an analysis of outcome data performed at the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical College of Wisconsin, Milwaukee...

THE simple act of sitting with his family on the couch of his suburban Melbourne home is more than Graham Barnell would have dared dream about six months ago. But after a two-year odyssey through the darkest ravages of a rare and deadly form of leukemia, Mr Barnell is apparently cured, thanks to a revolutionary procedure only now emerging in the US.

In a retrospective review of blood disorder patients treated with stem cells from their own cord blood (autologous transplant) or from the cord blood of a sibling (allogeneic-related transplant), the majority of the patients were cured or achieved remission from their disease, according to a report presented today at the American Society for Blood and Marrow Transplantation (ASBMT) annual meeting.

Horizon, Lifeblood – BBC

why it is difficult to find a match bone marrow - cord blood could be an alternative to bone marrow transplant - ethnic minorities. Moving video from BBC show Life Blood.

A leukaemia sufferer has become the first adult in the UK to undergo a bone marrow transplant using blood from a baby's umbilical cord. Stephen Knox, 31, underwent the treatment - previously only performed on children - after being given just months to live...

An experiment at the University of Minnesota has come up with a potential solution for the problem of mismatched bone marrow donors - mismatched umbilical cord blood donations.

No match could be found to provide bone marrow to help 4-year-old Taja Harris battle leukemia, until the birth of her brother whose cord blood gave the gift of life.

A team led by Mary J. Laughlin, MD, showed that the transplantation of cord blood following high dose chemotherapy and radiation, can save the lives of about one-third of adult patients for whom other treatments are likely to fail...

In summary, the demonstration that cell dose is the most important factor influencing outcome has led university physicians to develop new approaches to expand the stem cell pool either by expansion in the laboratory prior to transplantation, expansion by mixing two UCB units, or by expansion in the patient by co-infusing healthy stroma from one of the parents. While none of these approaches has been proven, support by the Children's Cancer Research Fund has been instrumental in allowing the development of new treatments with the ultimate goal of improving the rate of cure in children and adults with life-threatening diseases.

According to results recently presented at the 31st annual meeting of the European Group for Blood and Marrow Transplantation, umbilical cord blood transplants are effective treatment for adults with leukemia who lack an acceptable stem cell donor.

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