Lifeline Cord Blood

Bone fracture healing impairment related to mechanical problems has been largely corrected by advances in fracture management. Better protocols, more strict controls of time and function, and hardware and surgical technique evolution have contributed to better prognosis, even in complex fractures.

A jab of stem cells could help prevent pain while walking, ulcers and the need for amputation in patients with furred-up arteries in the leg. Now, researchers in Canada, South Korea and Malaysia are investigating the use of stem cells to help ease PAD.
In many tissues, stem cells serve as a sort of internal repair system, dividing constantly to replenish cells that might be damaged. Results from a pilot study with 22 patients at Tehran University, Iran, show that those who were given the stem cell injections were able to walk further without pain after six months than those given placebo jabs.

Telegraph.co.uk

Doctors in Southampton are using the pioneering technique, where a patient’s damaged bones are repaired using their own stem cells. Patients hailed the treatment, after many found they could walk normally again without any pain and without the need for hip replacement surgery...

Imagine you have a bone fracture or a hip replacement, and you need bone to form, but you heal slowly -- a common fact of life for older people. Instead of forming bone, you could form fat. Researchers at the University of North Carolina School of Medicine may have found a way to tip the scale in favor of bone formation.

Wang F, et al. Journal of Bone and Mineral Research

Study: Stem cells isolated from human cord blood were subjected to shockwave treatment to stimulate osteogenic differentiation. Researchers noted that the post-cultured cells induced noticeable bone healing when transplanted into mice with fractured femurs...

Charles Krome, DO, of Somers Point, N.J.-based Shore Orthopaedic, leverages stem cells to treat various orthopedic conditions, according to Cape May County Herald.
Here are four takeaways:

1. Dr. Krome combines stem cells from donated umbilical cord blood with patients' platelet rich plasma.

2. The stem cells help treat knee, hip, shoulder and ankle osteoarthritis; rotator cuff tears; tennis elbow; plantar fasciitis; meniscal and ligament injuries; and other conditions.

3. Dr. Krome injects the cells with ultrasound guidance.

4. He completed his sports medicine fellowship at Grant Medical Center in Columbus.

Original Article

LFLN REF:06032018, P.202

The MSC trial can complement the growing fields of personalized medicine and biologics (products isolated from natural sources such as humans or animals, produced with biotechnology, to become medicines). “This current trial is opening the door to precision medicine,” says Dr. Chahal. “It’s very exciting, and it allows us at UHN to create an infrastructure for world-class clinical trials related to stem cell therapy for arthritis. The next step is to become a world leader.”

For Barbara, the trial has improved her world, allowing her to occasionally don high heels and smile a lot more because she’s in less pain. “Sometimes I even forget about my knee.”

We have performed multiple pre-clinical studies that demonstrate that this approach improves healing of cleft palate defects in animals. These are being repeated in larger animals as required by the FDA prior to translating this approach to treat children with cleft lip and palate.  Once these final components are completed, we anticipate that clinical trials should begin within the next 12-18 months.